A Discussion on Chemoprevention of Oral Cancer by Selective Cyclooxygenase-2 (cox-2) Inhibitors
نویسندگان
چکیده
A. K. SINGH, A. PANDEY, M. TEWARI, KUMAR PRAKASH, H. S. SHUKLA, H. P. PANDEY Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi, India Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India Department of Biotechnology, IBMER, Mangalayatan University, Aligarh, India Department of Statistics, Faculty of Science, Banaras Hindu University, Varanasi, India
منابع مشابه
Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors.
Oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide (NQO) show substantial overexpression of cyclooxygenase-2 (COX-2) when compared with adjacent phenotypically normal oral tissues. By contrast, neither 5-lipoxygenase (LOX) nor 12-LOX is overexpressed in rat oral cancers. Two chemoprevention studies were done to test the resulting hypothesis that COX-2 is a useful target f...
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Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs). Their use is associated with the side effects such as gastrointestinal and renal toxicity. The therapeutic anti-inflammatory action of NSAIDs is produced by the inhibition of COX-2, while the ...
متن کاملSelective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships
Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs). Their use is associated with the side effects such as gastrointestinal and renal toxicity. The therapeutic anti-inflammatory action of NSAIDs is produced by the inhibition of COX-2, while the ...
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PL Numerous drug agents and drug classes have been evaluated as chemopreventive compounds for colorectal cancer prevention. The most widely studied are probably the nonsteroidal anti-inflammatory drugs and cyclooxygenase (COX)-2 selective inhibitors. Nonsteroidal agents, including aspirin and ibuprofen, appear to have a beneficial effect based on data primarily from observational studies, but a...
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The inducible prostaglandin synthase isoform cyclooxygenase-2 (COX-2) is overexpressed in approximately 40% of human breast carcinomas and in precancerous breast lesions, particularly in association with overexpression of human epidermal growth factor receptor 2 (HER2/neu). Experimental breast cancer can be suppressed by pharmacologic inhibition or genetic ablation of Cox-2, suggesting potentia...
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